ISETHIONATE SALT OF A SELECTIVE CDK4 INHIBITOR, A PHARMACEUTICAL DOSAGE FORM COMPRISING THE SAME, A METHOD FOR ITS PREPARATION AND USE THEREOF IN THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF DISEASES

摘要

Disclosed are polymorphs of the isethionate salt of 6-acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one, which is a selective cyclin-dependent kinase 4 (CDK4) inhibitor useful for treating inflammation and cell proliferative diseases such as cancer and restenosis.