AN IMPROVED PROCESS FOR THE PREPARATION OF NARATRIPTAN HYDROCHLORIDE

摘要

: The present invention provides a process for the preparation of Naratriptan hydrochloride which comprises decarboxylation of 5-{2-[(methylamino) sulfonyl] ethyl}-lH-indole-2-carboxylic acid to get 2-(lH-indol-5-yl)-N-methylethanesulfonamide using sulfolane as a solvent, and further reacting 2-(lH-indol-5-yl)-N-methylethanesulfonamide to obtain Naratriptan hydrochloride. No. of Pages : 15 No. of Claims : 10