IMPROVED DRUG DELIVERY SYSTEM FOR TREATMENT OF HYPERTENSION BY CHRONOTHERAPEUTIC DELIVERY APPROACH

摘要

The invention relates to a chronotherapeutic drug delivery system comprising of therapeutically effective amount of Atenolol, an antihypertensive agent along with Amlodipine and Atorvastatin that helps in optimization of anti-hypertensive therapy when administered at bed time. The invention takes into consideration the circadian rhythm of hypertension and the increase in cholesterol level generally associated with hypertension.