A NOVEL PROCESS FOR PREPARATION AND FORMULATION OF COLLOIDAL METAL NANOPARTICLES WITH NATURALLY OCCURING GUMS FOR THEIR APPLICATION IN DELIVERY OF BIOLOGICALS

摘要

The present invention is a process, which relates to colloidal metal nanoparticles and a synthesis method thereof, and more particularly to gold and silver nanoparticles, which can be synthesized by biocompatible polymer, poyeectroyte (Gellan Gum), which acts as reducing agent, stabilizing agent. More particularly, it relates to improved loading efficacy with wide range of biologically active substance e.g. therapeutic and diagnostic agents through electrostatic interactions on metal nanoparticles such that it can be employed for oral, nasal, pulmonary, buccal, ocular, vaginal or rectal administrations. In addition, it relates further capping of nanoparticles with biosurfactant (Sophorolipids) which aids in stabilization, surface modification, enable to bind to active biological molecules and helps in uptake of molecules across the biological membranes especially blood brain barrier.