A PROCESS FOR THE PREPARATION OF AN (ALKYNYLAMINO ALKYNYLOXY ALKYNYLTHIO OR ALKYNYLMETHYL ) HETEROARYL OR ARYL SULPHONYL OR PHOSPHINYL AMINO ACID N HYDROXYAMIDE

摘要

A process for preparing compounds of the formula: which are useful in treating disease conditions mediated by TNF- a, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.