unit dose formulations and methods of treatment of thrombosis with oral factor xa inhibitors.

摘要

the invention relates to unit doses of factor xa inhibitor compounds and methods for using these compounds to inhibit the coagulation of the blood in a human patient.the unit dose of the factor xa inhibitor compounds described in the present document necessary for anticoagulation in a primate, is smaller than the unit dose required to achieve similar levels of inhibition of blood clotting in other models of animals, such as q eu to rodents.the invention is also useful in vitro tests to predict the antithrombotic activity in vivo in humans.