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METHODS FOR ENHANCED PRODUCTION OF BONE MORPHOGENETIC PROTEINS.
METHODS FOR ENHANCED PRODUCTION OF BONE MORPHOGENETIC PROTEINS.
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机译:增强骨形态发生蛋白产量的方法。
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摘要
Methods and processes for improved recombinant protein production are provided. The methods are useful for production of growth factors, particularly those of the TGF-β superfamily, including bone morphogenetic proteins (BMPs), such as BMP-2. Suitable host cells are cultured in media where iron is present at a concentration of at least 2.25 μM and if pyridoxal is present, it makes up less than 55 % of the molar concentration of vitamin B6 in the media.
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