Novel Intermediates Useful For The Preparation Of Aripiprazole And Methods For The Preparation Of The Novel Intermediates And Aripiprazole

摘要

The disclosure relates to a process for the preparation of aripiprazole (1) which comprises (i) Reacting 6-hydroxy-1-indanone (11) with 1,4-dihalobutane (12) in the presence of a base and a solvent at a temperature in the range of 90 to 110 deg C to form the intermediate 6-(4-halo butoxy)-indan-1-one (3), (ii) reacting the intermediate (3) of step (i) with 1-(2,3-clichlorophenyl)-piperazine (9) to get another intermediate 6-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl] butoxy]-indan-1-one (2) and (iii) Reacting the resulting compound with sodium azide. The disclosure also relates to the intermediates of the formulae (2) & (3) and processes for their preparation.