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Methods of improving skin quality through topical application of an immune response modifier such as imiquimod

机译:通过局部应用免疫应答调节剂(如咪喹莫特)改善皮肤质量的方法

摘要

Disclosed is a method of visibly reducing a human skin wrinkle comprising: topically applying to the human skin wrinkle an IRM compound in an amount and for a period of time sufficient to visibly reduce the wrinkle; wherein the IRM compound is an imidazoquinoline amine (such as imiquimod), a tetrahydroimidazoquinoline amine, an imidazopyridine amine, a 1,2-bridged imidazoquinoline amine, a 6,7-fused cycloalkylimidazopyridine amine, an imidazonaphthyridine amine, a tetrahydroimidazonaphthyridine amine,À an oxazoloquinoline amine, a thiazoloquinoline amine, an oxazolopyridine amine, a thiazolopyridine amine, an oxazolonaphthyridine amine, a thiazolonaphthyridine amine, or a combination thereof. Also disclosed is the use of an IRM compound in the manufacture of a medicament for treating aging related skin conditions, or for preventing, reversing or reducing scarring of skin resulting from a surgical wound. (62) Divided Out of 542126
机译:公开了一种明显减少人的皮肤皱纹的方法,该方法包括:在人的皮肤皱纹上局部施用一定量的IRM化合物并持续足以明显减少皱纹的时间。其中IRM化合物是咪唑并喹啉胺(如咪喹莫特),四氢咪唑并喹胺,咪唑并吡啶胺,1,2-桥连的咪唑并喹胺,6,7-稠合的环烷基咪唑并吡啶胺,咪唑并吡啶吡啶胺,四氢咪唑并萘胺恶唑啉喹啉胺,噻唑并喹啉胺,恶唑烷吡啶胺,噻唑并吡啶胺,恶唑烷萘啶胺,噻唑并萘啶胺或其组合。还公开了IRM化合物在制备药物中的用途,该药物用于治疗与衰老有关的皮肤状况,或用于预防,逆转或减少由外科伤口引起的皮肤瘢痕形成。 (62)除以542126

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