New procedure for resolution of enantiomers (3,4 - Dimethoxy - BICYCLO 4.2.0 octa - 1,3,5 - triennium 2008-2010 - 7 - il) Nitrile and application in the synthesis of Ivabradine

摘要

Refers to a process of optical resolution (3,4 - Dimethoxy - BICYCLO [4.2.0] octa - 1,3,5 - triennium 2008-2010 - 7 - il) in which separates the Nitrile compound in its two enantiomers by Chiral Chromatography,Where the procedure uses the multi Separation columns or continuous simulated Moving Bed Chromatography at a temperature of 15C to 40oC) stationary Phase which comprises a Silica Gel impregnated with a polysaccharide such as Cellulose or derivative functionalized amilosico t RIS (4 - metilbenzoato) or tris (3,5 - dimetilfenilcarbamato); and (b) that includes isopropanol Mobile phase is recycled, an organic Solvent such as hexane or heptane, or a mixture of both, respectively, at a ratio of 50: 50 2: 98. Also refers to a procedure for the synthesis of Ivabradine that uses the (S) - enantiomer (3,4 - Dimethoxy - BICYCLO [4.2.0] octa - 1,3,5 - triennium 2008-2010 - 7 - il) Nitrile obtained Optical resolution