mix for quality control of the medicine 'Glycine tablets for sublingual applying 0.1' and its preparation method

摘要

The invention relates to the chemical-pharmaceutical industry and specifically to mix for quality control of the medicine "Glycine tablets for sublingual applying 0,1" and its preparation method. The method involves process of analysis by dissolution of 2,5g of porphyrized tablets in 250 ml of purified water and light transmission spectrophotometer examination at a wave length of 700±2 in a cuvet with layer thickness of 10 mm relative to purified water. Process of dissolution takes 20 minutes and is carried out at a temperature of 370°C in the apparatus for dissolving determination at a paddle rotation speed of 150 rpm. After mix is dissolved it is allowed for 10 minutes then there are selected 4ml for light transmission analysis. Mix for quality control deludes water in a ratio 100:1 to porphyrized tablets, containing in one tablet 0,101 g microcapsules of non-agglomerated crystals of amino-acetic acid covered with polymeric film of water-soluble methylcellulose, MC-100 and 0,001 g of magnesium stearate. Mix light transmission coefficient is within the limits of 50 to 70 % in comparison with purified water at a wave length 700±2 nm for 4 ml of mix and with layer thickness of 10 mm.