1,1,1- TRIFLUORO-4-PHENYL-4-METHYL-2-(1H-PYRROLO2,3-cPYRIDIN-2-YLMETHYL)PENTAN-2-OL DERIVATIVES AND RELATED COMPOUNDS AS GLUCOCORTICOID LIGANDS FOR THE TREATMENT OF INFLAMMATORY DISEASES AND DIABETES

摘要

Compounds of Formula (IA), IB), (IC), and (ID) wherein R, R, R, R, R, and Rare as respectively defined herein for Formula (IA), (IB), (IC), and (ID), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.(IA)(IB)(IC)(ID)