Azacarbolinas Derivatives, their Preparation and therapeutic use.

摘要

New azacarbolinas, derived from a (alpha) - aza - B (beta carbolines) of formula (i) in the ground State or an Acid Addition Salt and its Synthesis procedures, useful for the treatment of cancer, in particular those that act on Proteins of Chk1 kinase, Cdk1, Cdk2, d Yrk2, FLT3, gsk-3 beta, Mnk2, pdgrbeta, pim1, PIM2, pim3, Plk, TrkBAll involved in the development of cancers, and more particularly, to the Acting on a Target called PIM is involved in the development of cancers.