Delta-5 desaturase from peridinium SP and its use in making polyunsaturated fatty acids

摘要

The present invention relates to a 5 desaturase, which has the ability to convert dihomo--linolenic acid (DGLA; 20:3 -6) to arachidonic acid (ARA; 20:4 -6) and/or eicosatetraenoic acid (ETA; 20:4 -3) to eicosapentaenoic acid (EPA; 20:5 -3). Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding 5 desaturase along with a method of making long chain polyunsaturated fatty acids (PUFAs) using this 5 desaturase in oleaginous yeast are disclosed.