PROCESS FOR THE PREPARATION OF 1,3-DIHYDRO-2H-3-BENZAZEPIN-2-ONE AND APPLICATION TO THE PREPARATION OF IVABRADINE AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS

摘要

PROCESS FOR THE SYNTHESIS OF COMPOUNDS OF FORMULA (1) : @@@@ WHEREIN R1 AND R2, WHICH MAY BE THE SAME OR DIFFERENT, EACH REPRESENT A LINEAR OR BRANCHED (C1-C8)ALKOXY GROUP OR FORM, TOGETHER WITH THE CARBON ATOM CARRYING THEM, A 1,3-DIOXANE, 1,3-DIOXOLANE OR 1,3-DIOXEPANE RING. APPLICATION IN THE SYNTHESIS OF IVABRADINE, ADDITION SALTS THEREOF WITH A PHARMACEUTICALLY ACCEPTABLE ACID, AND HYDRATES THEREOF.