IMMUNOGENOUS BETA-PROPIONAMIDO-BOUND POLYSACCHARID PROTEIN CONJUGATE IS SUITABLE FOR VACCINATION AND MANUFACTURING OF N-ACRYLYLATED POLYSACCHARIDE

摘要

Novel immunogenic beta-propionamido-linked polysaccharide- and N-propionamido-linked oligosaccharide-protein conjugates are provided as well as method of producing the conjugates. The conjugation procedure is simple, rapid, reproducible and applicable to a variety of polysaccharides or oligosaccharides derived from bacterial species, yeast, cancer cells or chemically synthesized. Vaccines and methods of immunization against infection or cancer using the immunogenic beta-propionamido-linked polysaccharide- and beta-propionamido-linked oligosaccharide-protein conjugates are also disclosed.