N-HYDROXY-3- (4-Ä3-PHENYL-3-OXOPROPENYLÜPHENYL) ACRYLAMIDE DERIVATIVES AND RELATED COMPOUNDS AS HISTONDEACETYLASEINHIBITORS FOR THE TREATMENT OF CANCER

摘要

New histone deacetylase inhibitors according to the general formula (I) wherein: Q is a bond, CH2, CHNR3R4, NR5 or oxygen, X is CH or nitrogen, Y is a bond, CH2, oxygen or NR6, Z is CH or nitrogen, R1, R2 are, independently, hydrogen, halogen, C1-C6 alkyl or C1-C6 haloalkyl, R11, R12 are, independently, hydrogen or C1-C6 alkyl, and R3, R4, R5 and R6 are as further defined in the specification.