Identification of protein-interactions of compounds using libraries fusion molecules protein-nucleic acid.

摘要

A method for detecting a compound-protein interaction, said method comprising: (a) providing a library of coded or addressable compound covering a plurality of different compounds, wherein said compounds are immobilized on a solid support; (B) simultaneously contacting said different immobilized compounds in a single reaction chamber with each member of a library of fusions of protein-nucleic acid under conditions allowing complex formation fusion compounds; (C) isolating said fusion complexes of immobilized compounds; and (d) detecting said compound-fusion complex as an indication that the protein of said fusion interacts with said compound.