DERIVATIVES OF 4 (4-ALKOXI-3-HIDROXIFENIL) -2-PIRROLIDONE AS PDE-4 INHIBITORS FOR THE TREATMENT OF NEUROLOGICAL SYNDROMES.

摘要

Compound of formula I: ** (See formula) ** in which R1 is 3 (R) -tetrahydrofuranyl; R2 is alkyl with 1 to 4 carbon atoms, which is unsubstituted or substituted one or more times by halogen; R3 is H, arylalkyl with 7 to 16 carbon atoms, which is unsubstituted or substituted one or more times by halogen, alkyl, hydroxy, alkoxy, nitro, methylenedioxy, ethylenedioxy, amino, alkylamino, dialkylamino, hydroxyalkyl, hydroxyalkoxy, carboxy, cyano , acyl, alkoxycarbonyl, alkylthio, alkylsulfinyl, alkylsulfonyl, phenoxy and acyloxy, or combinations thereof, heterocyclic alkyl group, which is saturated, partially saturated or completely unsaturated, having 5 to 10 ring atoms where at least 1 ring atom it is an N, O or S atom, which is unsubstituted or substituted one or more times in the heterocyclic portion by halogen, aryl, alkyl, alkoxy, cyano, trifluoromethyl, nitro, oxo, amino, alkylamino, dialkylamino, carboxy or combinations thereof. same and / or substituted in the alkyl portion by halogen, oxo, cyano, or combinations thereof. alkoxyalkyl with 3 to 8 carbon atoms, -C (O) R4, or -CH2CONHR5; R4 is aryl with 6 to 14 carbon atoms, i.e. unsubstituted or substituted one or more times by halogen, CF3, OCF3, alkyl, hydroxy, alkoxy, nitro, methylenedioxy, ethylenedioxy, amino, alkylamino, dialkylamino, hydroxyalkyl, hydroxyalquoxy, carboxy , cyano, acyl, alkoxycarbonyl, alkylthio, alkylsulfinyl, alkylsulfonyl, phenoxy, acylamido and acyloxy, or combinations thereof, or a heterocyclic group, which is saturated, partially saturated or completely unsaturated, with 5 to 10 ring atoms in which at least 1 ring atom is an N, O or S atom, which is unsubstituted or substituted one or more times by halogen, aryl, alkyl, alkoxy, cyano, trifluoromethyl, nitro, oxo, amino, alkylamino, dialkylamino, or combinations of the same; and R5 is aryl with 6 to 14 carbon atoms, which is unsubstituted or substituted one or more times by halogen, CF3, OCF3, alkyl, hydroxy, alkoxy, nitro, methylenedioxy, ethylenedioxy, amino, alkylamino, dialkylamino, hydroxyalkyl, hydroxyalquoxy, carboxy, cyano, acyl, alkoxycarbonyl, alkylthio, alkylsulfinyl, alkylsulfonyl, phenoxy, acylamido and acyloxy, or combinations thereof, or a heterocyclic group, which is saturated, partially saturated or completely unsaturated, with 5 to 10 ring atoms where minus 1 ring atom is an N, O or S atom, which is unsubstituted or substituted one or more times by halogen, aryl, alkyl, alkoxy, alkoxycarbonyl, cyano, trifluoromethyl, nitro, oxo, amino, alkylamino, dialkylamino, or combinations thereof, with the proviso that: (a) when R2 is CH3, R3 is not H.