SEQUENCES OF NUCLEOTIDES AND PROTEINS OF DELTA GENES OF VERTEBRATES AND METHODS BASED ON THE SAME.

摘要

THE PRESENT INVENTION IS RELATED TO SEQUENCES OF NUCLEOTIDES OF DELTA GENES OF VERTEBRATES AND SEQUENCES OF AMINO ACIDS OF THE PROTEINS THAT CODE, AS WELL AS DERIVATIVES (eg, FRAGMENTS) AND ANALOGS OF THE SAME. IN A SPECIFIC EMBODIMENT, DELTA VERTEBRADOS PROTEIN IS A HUMAN PROTEIN. THE INVENTION IS RELATED TO DELTA FRAGMENTS (AND DERIVATIVES AND ANALOGS OF THE SAME) THAT COVER ONE OR MORE DOMAINS OF THE DELTA PROTEIN, INCLUDING BUT NOT LIMITED TO THE INTRACELLULAR DOMAIN, THE EXTRACELLULAR DOMAIN, DSL DOMAIN DOMAIN DOMAIN DOMAIN , THE TRANSMEMBRANE REGION OR ONE OR MORE EGF TYPE REPETITIONS OF A DELTA PROTEIN, OR ANY COMBINATION OF THE PREVIOUS. ANTIBODIES ARE ALSO PROVIDED AGAINST DELTA PROTEIN AND ITS DERIVATIVES AND ANALOGS. METHODS OF PRODUCTION OF DELTA PROTEINS AND THEIR DERIVATIVES AND ANALOGS, P.E., ARE ALSO PROVIDED THROUGH RECOMBINANT TECHNIQUES. THERAPEUTIC AND DIAGNOSTIC METHODS AND PHARMACEUTICAL COMPOSITIONS ARE PROVIDED. IN SPECIFIC EXAMPLES, DELTA ISOLATED GENES OF XENOPUS, CHICK, MOUSE AND HUMAN BEINGS ARE PROVIDED.