NEW PROTEINS ASSOCIATED WITH THE DEATH OF THE THAP FAMILY AND RELATED PAR4 ROUTES INVOLVED IN THE CONTROL OF APOPTOSIS.

摘要

A method for identifying a test compound that modulates THAP-mediated activities ("THanatos-Associated Protein", death-associated protein), comprising: contacting a THAP family polypeptide, or its biologically active fragment, with a test compound, wherein said THAP family polypeptide comprises an amino acid sequence having at least a 70% amino acid match with an amino acid sequence of SEQ ID NO: 3; and determining whether said test compound selectively modulates the activity of said THAP family polypeptide, or its biologically active fragment, wherein a determination that said test compound selectively modulates the activity of said polypeptide indicates that said test compound is a candidate modulator of activities mediated by THAP.