FENIL-METANONAS BI- AND TRICYCLES REPLACED AS INHIBITORS OF THE GLICINE I CARRIER (GLYT-1) FOR THE TREATMENT OF ALZHEIMER'S DISEASE.

摘要

Compounds of the general formula ** (See formula) ** in which 59 is ** (See formula) ** R1 is a non-aromatic heterocycle or is OR '' or N (R '' ') 2; R '' is C1-C7 alkyl, C1-C7 alkyl substituted by halogen or is - (CH2) n-cycloalkyl; R '' '' is C1-C7 alkyl; R2 is NO2, CN or SO2R '' ''; R3 is hydrogen, halogen, C1-C7 alkyl, C1-C7 alkoxy or C1-C7 alkyl substituted by halogen; R4 is hydrogen, C1-C7 alkyl, halogen-substituted phenyl or CF3 or is a five or six link aromatic heterocycle; R5 / R6 are hydrogen, halogen, C1-C7 alkyl, C1-C7 alkoxy or are C1-C7 alkyl or C1-C7 alkoxy substituted by halogen; R7 is hydrogen or C1-C7 alkyl; n is 0, 1 or 2; and its pharmaceutically active acid addition salts.