PROCESS FOR PREPARING POLYMER COATINGS GRAFTED WITH POLYETHYLENE OXIDE CHAINS CONTAINING COVALENTLY BONDED BIO-ACTIVE AGENTS

摘要

Disclosed are bio-active coating compositions for polymeric substrates. Inparticular, a bio-active coating is described which is thereaction product formed by providing a polymer backbone with at least one freeisocyanate group, wherein the isocyanate group is pendantfrom the polymer backbone. There is further provided a hydrophilic, amine-terminated spacer which has at least one amine group at its firstand second ends. One of the amine groups of the spacer is reacted with one ormore of the isocyanate groups on the polymer backbone inthe presence of an optional catalyst agent. A bio-active agent is thencovalently bonded onto an unreacted end of the spacer in the presenceof a catalyst. Also disclosed are coating compositions for a substrate andmethods of preparing same.