THERAPEUTIC INTERVENTION TO MIMIC THE EFFECT OF CALORIC RESTRICTION

摘要

Methods are provided for promoting longevity and decreasing the incidence ofaging associated pathologies (e.g., cancer) by the administration of one ormore of the following LFFA: linoleic, oleic and palmitic acid. Secondary LFFAderived from this set, as well as their CoA derivatives and synthetic analogs,are effective also in promoting longevity and delaying the onset of ageassociated disorders. In addition, interventions including LFFA and CoA LLFAformulations are described which protect the organism from acute physicalstress, tissue damage and hypoxia (either due to trauma or secondary tosurgical procedures).