METHOD, COMPOSITION, AND DEVICE, FOR THE TREATMENT OF AMYLASE ACTIVITY MALFUNCTIONS / INACTIVITY IN ASSOCIATION WITH SACCHARIDES (MAINLY POLYSACCHARIDES) BASED DISEASES

摘要

Physiological enzyme complex having active amylases, active lipases, andactive proteases, of human (saliva or pancreatic enzymes), yeast, plant,fungi,and or microbial origin, preferably digestive enzyme complex such as,4.alpha.D-glucan glucanohydrolase; Exo-1,4.alpha.glucosidase; Beta-fructofuranosidase;Protease (3.0); Pectinase; Lipase; Cellulase; Lactase; Malt Diastase, ordigestiveenzyme complex containing salivary like enzymes , gastric like proteins andenzymes, pancreatic like enzymes for the treatment of high levels / highexcessof polysaccharides and disaccharides, correction, and treatment of amylasesmalfunctioning activity or amylases inactivity. Correction and treatment ofhighlevels of saccharides in the body, in association with or withoutmalfunctioning(delayed activity) and or absence of amylases (4.alpha.D-glucanglucanohydrolase;Exo-1,4.alpha.glucosidase; Beta-fructofuranosidase; Protease (3.0); Pectinase;Lipase; Cellulase; Lactase; Malt Diastase) enzyme activity. The invention alsorelates to the production of pharmaceutical compositions suitable for suchtreatment. A preferred variant of the invention relates to use of this enzymecomplex having amylolytic, lipolytic, and proteolytic activity, especiallysalivary,gastric, pancreatic and intestinal enzyme complex such as ,4.alpha.D-glucanglucanohydrolase; Exo-1,4.alpha.glucosidase; Beta-fructofuranosidase; Protease(3.0); Pectinase; Lipase; Cellulase; Lactase; Malt Diastase or digestiveenzymecomplex containing ,4.alpha.D-glucan glucanohydrolase; Exo-1,4.alpha.glucosidase;Beta-fructofuranosidase, for the treatment of excess polysaccharides in thebody in association with or without malfunctioning, delayed or absentamylases (4.alpha.D-glucan glucanohydrolase; Exo-1,4.alpha.glucosidase;Beta-fructofuranosidase; Protease (3.0); Pectinase; Lipase; Cellulase;Lactase; MaltDiastase) enzyme activity but not deficiency. According to the invention,normal ranges of amylases activity are: 30 to 120 minutes for the degradationof disaccharides by the disaccharides specialised amylases (disaccharidesspecialised salivary, pancreatic or systemic amylases were not known before),and 4 to 6, up to 8 hours for the degradation of polysaccharides bypolysaccharides specialised amylases. Tests results for amylase activity onpolysaccharides, and amylase activity on disaccharides is compared to anormal range of 30 to 120 minutes for disaccharides, and 4 to 8 hours forpolysaccharides (meaning: 50 to 250 mg/dl of glucose detected in adisaccharide test sample within 30 to 120 minutes, and 55 to 250 mg/dl ofglucose to be detected in a polysaccharides sample within 4 to 8 hours).Normal range for disaccharides and polysaccharides are the ranges detected ina healthy non polysaccharides, oligosaccharides, disaccharides andmonosaccharides diseases, non diabetic, non diseased individuals in a lowendemic diabetes area (normal range figures obtained from healthy subjects inwestern Sudan and Darfur region where diabetes is approximately 7% of thepopulation). Normal ranges for the tests can also be compared from thefollowing calculations: Glucamylase: 1 unit of enzyme activity catalyzes theproduction of 1.0mg (1.0ml) of glucose in 1 hour under the followingcondition:40 C pH = 4.6, Amylase: 1 unit of enzyme activity is the amount of enzyme thatwill dextrinize 1.0mg (1.0ml) of soluble starch in 1 hour under the followingcondition: 60 C pH = 6.0, High temperature amylase: 1 unit of enzyme activityis the amount of enzyme that will dextrinize 1.0mg (1.0ml) of soluble starchin1 hour under the following condition: 70 C pH = 6Ø