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Pleiotrophin growth factor receptor for the treatment of proliferative, vascular and neurological disorders
Pleiotrophin growth factor receptor for the treatment of proliferative, vascular and neurological disorders
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机译:促营养素生长因子受体用于治疗增殖,血管和神经系统疾病
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摘要
This invention relates to the discovery that pleiotrophin binds to and activates a pleiotrophin-receptor which is responsible for the events associated with pleiotrophin activity including tumorigenesis, cell proliferation, and cell invasion. By interfering with that association, the cascade of events associated with pleiotrophin activity can be prevented or reversed. Further, by evaluating the effect of different compounds and conditions on the interaction, new drugs and treatments can be identified for use in preventing certain cancers and growth and developmental disorders.
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