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Reagents and methods for the determination of PK/ADME-tox characteristics of new chemical entities and of drug candidates
Reagents and methods for the determination of PK/ADME-tox characteristics of new chemical entities and of drug candidates
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机译:测定新化学实体和候选药物的PK / ADME-tox特性的试剂和方法
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摘要
Methods using colloidal conductive polymers, noble metal nanoparticles or of stable metal/conductive polymer composite colloids as reagents for at least the in vitro prediction of, if not the determination of, PK/ADME-tox properties of new chemical entities (NCEs) are provided. Also provided are kits that include the subject methods and reagents for application thereof. The salient characteristicsof these methods and reagents pertaining to the present invention reside in the fact that the reactions in which they are involved are homogeneous, rapid, and proceed as 'mix and read' processes.
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