The present invention relates generally to heteroreceptor G-protein coupled receptors, and more specifically to a heteroreceptor complex comprising serotonin and glutamate receptors, as well as to methods for identifying modulators (agonists and antagonists) of such receptors. The invention also relates to identification of novel heteroreceptor ligands and synergistic compositions, which can provide strategies for relieving psychosis associated with schizophrenia or hallucinogenic drug use.
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