POORLY SOLUBLE DRUG-CONTAINING RELEASE-CONTROLLED POLYMERIC NANOPARTICLE FORMULATION

摘要

The present invention relates to a release-controlled polymeric nanoparticle formulation containing biphenyl-dimethyl-dicarboxylate, a poorly soluble drug, and more particularly, to a nano-sized polymer formulation having a particle size distribution of narrow range, in which the biphenyl-dimethyl-dicarboxylate, a poorly soluble drug, is impregnated in biodegradable polymer and the surface of the formulation is coated with an emulsifier. The polymeric nanoparticle formulation according to the present invention can be effectively used in the treatment of hepatic disease since the formulation enhances the dissolution rate of biphenyl-dimethyl-dicarboxylate which is a poorly soluble drug to increase bioavailability, and releases drugs gradually to keep the drugs at a constant density in blood over a long period of time. The polymeric nanoparticle formulation of the present invention may prevent an excessive use of biphenyl-dimethyl-dicarboxylate caused due to the low dissolution rate in a body and low bioavailability of conventional formulations containing biphenyl-dimethyl-dicarboxylate.