INHALED CARBAPROSTACYCLIN AND PROSTACYCLIN PRODRUGS FOR THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSION

摘要

Phenylphosphonate prodrugs comprising one or more prostacyclins are provided for the treatment of pulmonary arterial hypertension. Also provided are inhalable formulations of the prodrugs for delivery by aerosolization or dry powder. The compounds and formulations are useful for producing pulmonary vasodilation and for treating pulmonary arterial hypertension.