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METHOD FOR IDENTIFYING TARGET PROTEIN OF AGENT AND METHOD FOR SCREENING THERAPEUTIC AGENT FOR DIABETES USING TARGET PROTEIN
METHOD FOR IDENTIFYING TARGET PROTEIN OF AGENT AND METHOD FOR SCREENING THERAPEUTIC AGENT FOR DIABETES USING TARGET PROTEIN
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机译:识别靶标蛋白的方法和使用靶标蛋白筛选糖尿病治疗剂的方法
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摘要
A method for identifying a target protein of a compound having a pharmacological action by detecting a tertiary structural change of a target protein by binding a compound having a pharmacological action to a target protein with the use of a molecular chaperone protein having a characteristic of binding to a protein by recognizing a tertiary structural change of the protein is disclosed. Further, a method for screening a therapeutic agent for diabetes using a target protein of biguanide which is a therapeutic agent for diabetes and was found by the identification method, a screening tool which can be used in the screening method and a pharmaceutical composition for treating diabetes containing a substance obtained by the screening method are disclosed.
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