PROTEINS CONTAINING EXPANDED POLYGLUTAMINE TRACTS INDUCE MITOCHONDRIAL FRAGMENTATION BY DISRUPTING MITOCHONDRIAL FUSION

摘要

Expanded polyglutamine tracts are shown to be a cause of disturbance of mitochondrial function and therefore a cause of cell toxicity and cell death and a cause of various diseases or disorders related to such effects. Such diseases and disorders may include neurodegenerative diseases or disorders, such as Huntington's Disease, Spinocerebellar ataxias, spinal and bulbar muscular atrophy, and dentatorubral-pallidoluysian atrophy. Methods for controlling such cell death, cell toxicity and/or related diseases or disorders are described. Also described is treatment of such neurodegenerative diseases or disorders.