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PROCESS FOR ACYL-TRANSFER ENZYME REACTIONS WITH ACYL- COENZYME A

机译：酰基辅酶A与酰基转移酶的反应过程

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摘要

The present invention relates to a method for acyltransferase reaction in which an acyl group of acyl coenzyme A is transferred to an acyl group receptor characterized in that the reaction is carried out by production and/or reproduction of acyl coenzyme A from coenzyme A in a reaction system by a chemical thioester exchange reaction with acylthioester. The present invention, wherein expensive acyl CoA is reproduced nonenzymatically in a reaction system, enables to continuously carry out acyltransferase reaction only by putting a small amount of acyl CoA with a donor and a receptor of an acyl group into a system. Accordingly, the method of the present invention can be applied to an industrial production method of various kinds of compounds including useful biological molecules and synthesis of polylmers such as polyester.

机译：酰基转移酶反应的方法本发明涉及一种酰基转移酶反应的方法，其中酰基辅酶A的酰基转移到酰基受体，其特征在于，该反应通过酰基辅酶的产生和/或繁殖进行。通过化学硫酯与酰基硫酯的交换反应，在反应体系中由辅酶A得到A。本发明，其中在反应系统中非酶促地复制昂贵的酰基CoA，仅通过将少量的酰基CoA与供体和酰基的受体一起放入系统中就能够连续进行酰基转移酶反应。因此，本发明的方法可以应用于各种化合物的工业生产方法，包括有用的生物分子和诸如聚酯的聚合体的合成。 展开▼

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公开/公告号EP1591531A4

专利类型

公开/公告日2010-01-27

原文格式PDF

申请/专利权人 SHOWA DENKO K.K.;
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申请/专利号EP20040703935

发明设计人 ERATA TOMOKI;KAMACHI HARUMI;TAJIMA KENJI;AOKI HIROBUMI;KAMACHI MOTOAKI;
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申请日2004-01-21

分类号C12P7/62;C12N9/10;C12N15/54;

国家 EP

入库时间 2022-08-21 18:39:41

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