SOLID STATE SYNTHESIS HYDROXYL RADICALS FOR HIGH-THROUGHPUT STRUCTURE DETERMINATION OF PROTEINS AND NUCLEIC ACIDS BY OXIDATIVE FOOTPRINTING

摘要

The present invention generally relates to an apparatus for structural mapping of a macromolecule comprising an amount of persulfide effective to generate hydroxyl radicals upon contact with an aqueous solution. The present invention further relates to methods for structural mapping a macromolecule in an aqueous solution and methods for structural mapping a plurality of macromolecules in parallel, wherein each macromolecule is in a separate aqueous solution.