COMPOSITION COMPRISING SILIBININ AT DETERMINED CONCENTRATIONS AND COMBINED PREPARATION COMPRISING SILIBININ AND A PI3K/AKT PATHWAY INHIBITOR FOR THE TREATMENT OF CANCER

摘要

The present invention relates to the use of a composition comprising silibinin in the required proportion to attain concentrations in serum equal to or exceeding 250 μM, or alternatively silibilin and an Akt inhibitor, for the preparation of a medicament for the treatment of cancer, and a combined preparation of, at least, silibinin and an inhibitor of the PI3K/Akt pathway, for the separate, simultaneous or sequential use thereof in the treatment of cancer.