HOLLOW MESOPOROUS SILICA SPHERE COATED WITH GOLD AND PREPARATION METHOD THEREOF AND USE IN CANCER THERAPY

摘要

A method relates to the preparation of hollow submicron silicon dioxide sphere coated gold shell and the use for preparing antitumor medicine. The hollow submicron silicon dioxide sphere is made as core and the gold shell is coated uniformly on the surface of the sphere. The antitumor medicine is loaded on the hollow submicron silicon dioxide sphere and the tumor specific targeting agent is coupled with the surface of the gold shell. The particle size of the hollow submicron silicon dioxide sphere and the thickness of the gold shell are controllable. Based on the Mie Scattering Theory, the hollow submicron silicon dioxide sphere coated gold shell can adjust its absorption in near-infrared area and converts light energy of infrared laser into peripheral heat which can kill the malignant tumor cell. The hollow submicron silicon dioxide sphere can be used as a slow-release carrier of therapeutic medicine, and the tumor specific targeting agent coupled with the surface of the gold shell can make the medicine have the function of targeting.