A USE OF THE LIQUIRITIGENIN ABUNDANT EXTRACT OR LIQUIRITIGENIN DERIVED THEREFROM FOR INCREASING BILE FLOW, CHOLERETIC EFFECT, AND FOR PREVENTING AND TREATING CHOLESTATIC LIVER DISEASES

摘要

The present invention is related to a composition comprising an extract of licorice or liquiritigenin derived therefrom, which significantly increases bile flow rate and biliary excretion of bile acid, GSH and bilirubin. Consistent with these results, the inventive composition comprising an extract of licorice or liquiritigenin derived therefrom decrease the blood chemical markers including ALT as a hepatoprotective marker, and ALP and γ-GTP, as cholestatasis markers, and histochemical markers including central necrosis and inflammation in galactosamine/lipopolysaccharide-induced hepato-toxicity animal model when the inventive extract or compound of the present invention was orally and intravenously administrated thereto.