ACTIVATION-INDUCED CYTIDINE DEAMINASE INHIBITOR SUPPRESSION OF AUTOIMMUNE DISEASES

摘要

The present disclosure encompasses methods for reducing or eliminating autoantibody formation in a host animal by inhibiting endogenous activation-induced cytidine deaminase (AID) activity. The present disclosure also encompasses transgenic animals. Genetic and pharmacologic inhibition of AID resulted in decreased autoantibody production, and suppression of arthritis and renal disease in the mouse model, indicating the important contribution of AID in autoimmune disease. The disclosure provides methods that comprise administering to a subject animal an effective amount of a therapeutic composition comprising an activation-induced cytidine deaminase inhibitor compound. In one embodiment of the disclosure, the inhibitor of the activation-induced cytidine deaminase activity is tetrahydrouridine (1-(-D-ribofuranosyl)-4-hydroxytetrahydro-1 (1 H)-pyrimidinone).