NEW 4,6-DISUBSTITUTED 2-(4-METHYLPIPERAZIN-1-YL)PYRIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITION CONTAINING THESE COMPOUNDS, THEIR USE, A METHOD FOR MODULATING MONOAMINERGIC RECEPTOR ACTIVITY AND A MONOAMINERGIC RECEPTOR MODULATING AGENT

摘要

The subjects of the invention are new 4,6-disubstituted 2-(4-methylpiperazin-1-yl)pyridine derivatives, a process for their preparation, pharmaceutical composition containing these compounds, their use, a method for modulating brain monoaminergic receptor activity and a monoaminergic receptor modulating agent. The invention relates to new chemical compounds, 2-(4-methylpiperazin-1-yl)pyridine derivatives, enantiomers thereof or a mixture of its enantiomers or their pharmaceutically permissible prodrugs and salts, pharmaceutical compositions containing these compounds, and methods of using any of these derivatives and compositions for the prevention or treatment of neurological or psychiatric diseases, especially related with the modulation or regulation of brain monoaminergic receptors such as serotonin receptors, preferably receptors selected from the group of: 5-HT6, 5-HT2A, 5-HT7, dopamine receptors, preferably D2 and adrenergic receptors, preferably α. These new compounds can be used for treating central nervous system diseases.