METHODS OF DIAGNOSING AND PREDICTING CROHNS DISEASE FROM CHILDHOOD HYGIENE AND SEROLOGICAL PROFILES

摘要

The present invention relates to the discovery that there is a different pathophysiology of inflammatory bowel disease in rural vs. urban areas. In one embodiment, a clean environment is positively associated with ASCA expression, but negatively associated with anti-OmpC and anti-I2 expression in subjects with Crohn's Disease. In another embodiment, the present invention provides a method of diagnosing susceptibility to Crohn's Disease in an individual by determining the presence or absence of risk factors, including serological profiles and sanitary conditions during the individual's childhood.