THE DRUG DELIVERY VEHICLE USING GOLD-MAGNETIC COMPOSITE PARTICLES COATED BY POLYSACCHARIDES AND ITS PREPARATION

摘要

The gold-magnetic composite particles can be coated by the biodegradable polysaccharide polymers such as dextran or cyclodextrin. This gold-magnetic composite particles coated by polysaccharides have better biocompatibility and drug-loading and can be used as drug delivery vehicle. The preparation of the drug delivery vehicle includes： preparing the gold-magnetic composite particles coated by polysaccharides first and loading the drug on the gold-magnetic composite particles coated by polysaccharides. The drug-loading process is carried out through directly mixing the gold-magnetic composite particles coated by polysaccharides with the drug solution by the shaker. That means the gold-magnetic composite particles coated by polysaccharides load the drug through affinity absorption.