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TRANSGENIC RODENTS HAVING NGF BETA GENE MUTANTS AND ITS PREPARATION METHODS, THE PREPARATION METHODS OF THE CORRESPONDING MUTANT PROTEINS AND THE RESULTING MUTANT PROTEINS
TRANSGENIC RODENTS HAVING NGF BETA GENE MUTANTS AND ITS PREPARATION METHODS, THE PREPARATION METHODS OF THE CORRESPONDING MUTANT PROTEINS AND THE RESULTING MUTANT PROTEINS
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机译:具有NGFβ基因突变体的转基因啮齿类动物及其制备方法,相应突变蛋白的制备方法和产生的突变蛋白
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摘要
The present invention provides a transgenic rodent, wherein the genome of said rodent comprising the mutant of NGF-² gene, said rodent expressing the mutein of NGF-². The present invention also provides the method for obtaining the transgenic rodent, and the methods of preparing the corresponding mutein of mutant NGF-² gene, and the protein obtained using this method. The present invention provides a new way to produce human NGF, and exploit a new way to investigate the function of Mutant NGF-² and its receptor in the level of whole animal, and to screen and purify the mutant NGF-² of high activity and safety.
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