THERAPY OPTION FOR RECOLORATION OF HAIR VIA BISPHOSPHONATES BY PHYSIOLOGICAL REPIGMENTATION WITH AGE-RELATED AND/OR PREMATURE 'GRAYED' PATIENTS

摘要

The present invention relates to the use of a bisphosphonate derivative according to general Formula I and/or a pharmaceutically acceptable salt thereof, wherein R 1 and/or R 2 are independently selected out of a group comprising hydrogen, hydroxyl, halogen, pseudohalogen, formyl, carboxy- and/or carbonyl derivatives, alkyl, long-chain alkyl, alkoxy, long-chain alkoxy, cycloalkyl, halogenalkyl, aryl, arylene, halogenaryl, heteroaryl, heteroarylene, heterocycloalkylene, heterocycloalkyl, halogenheteroaryl, alkenyl, halogenalkenyl, alkinyl, halogenalkinyl, keto, ketoaryl, halogenketoaryl, ketoheteroaryl, ketoalkyl, halogenketoalkyl, ketoalkenyl, halogenketoalkenyl, phosphoalkyl, phosphonate, phosphate, phosphine, phosphine oxide, phosphoryl, phosphoaryl, sulphonyl, sulphoalkyl, sulphoarenyl, sulphonate, sulphate, sulphone, amine, polyether, silylalkyl, silylalkyloxy, and wherein at appropriate residues one or more non-adjacent CH 2 -groups may be replaced independently from each other with -O-, -S-, -NH-, -NR°-, -SiR°R°°-, -CO-, -COO-, -OCO-, -OCO-O-, -SO 2 -, -S-CO-, -CO-S-, -CY 1 =CY 2 or -C=C- in that way that O and/or S-atoms are not connected directly with each other, likewise replaced optionally with aryl- or heteroaryl which preferably contain 1 to 30 C-atoms (terminal CH 3 -groups are meant as CH 2 -groups in terms of CH 2 -H), wherein R°, R°°, Y 1 and Y 2 are independently selected out of a group comprising alkyl and aryl, AH:SH in the manufacture of a pharmaceutical for the treatment of age-related and/or premature graying of hair.