METHOD FOR CONTROL OF NONSENSE-MEDIATED MRNA DECAY USING GENE PNRC2

摘要

PURPOSE: A method for regulating NMD(nonsense-mediated mRNA decay) using PNRC2 is provided to control NMD efficiency and develop therapeutic agent or inhibitor of cancer and NMD-related hereditary disease. CONSTITUTION: An NMD inhibitor contains a DNA which suppresses the PNRC2(Human proline-rich nuclear receptor coregulatory protein 2) expression. A DNA which suppresses PNRC2 expression contains small interfering double-stranded RNA(siRNA) of sequence number 3 or 4. A protein with an amino acid sequence of the sequence number 2 relates to pioneer round of translation.