METHOD FOR PREPARING MACAMIDES USING RECYCLING PREPARATIVE LIQUID CHROMATOGRAPHY, WHICH CAN REDUCE USED AMOUNT OF ORGANIC SOLVENT

摘要

PURPOSE: A method for preparing macamides is provided to rapidly prepare N-benzyl hexadecane amide and N-benzyl-5-oxo-6E,8E-octadecadiene amide, that are a kind of macamides, by using a recycling preparative liquid chromatography.;CONSTITUTION: A method for preparing macamides using a recycling preparative liquid chromatography comprises the steps of: taking a supernatant by extracting dried Lepidium meyenii powder with methanol at 70~80 °C for 12 hours; performing separation by injecting the supernatant in a recycling preparative liquid chromatography compring a reversed-phase column, wherein the mobile phase is 100% acetonitrile; and obtaining N-benzyl hexadecane amide and N-benzyl-5-oxo-6E,8E-octadecadiene amide through two-step refining process.;COPYRIGHT KIPO 2010