2,4-DISUBSTITUTED-5-AMINOCARBONYL-1,3-THIAZOLE DERIVATIVES FOR THERAPEUTIC AGENT OF ANTIINFLAMMATORY DISEASE, METHOD THEREOF FOR PREPARATION, THERAPEUTIC AGENT FOR ANTIINFLAMMATORY DISEASE INDUCED BY SPC ACTIVITY CONTAINING THE SAME

摘要

PURPOSE: A 2,4-double substitution-5-aminocarbonyl-1,3-thiazole derivative is provided to suppress sphingosylphosphorylcholine(SPC) receptor and to treat diseases caused by SPC receptor. CONSTITUTION: A method for preparing 2,4-double substitution-5-aminocarbonyl-1,3-thiazole derivative of chemical formula 1 comprises: a step of reacting 2-chloroacetoamide derivative with thio aminocarbonate to obtain a compound of chemical formula 3; a step of polymerizing chloridation carboxylic acid with 4-amino group of the compound of chemical formula 3 to obtain a compound of chemical formula 4; a step of oxidizing sulfanyl linker resin part of the compound of chemical formula 4 to synthesize the compound of chemical formula 5; and a step of performing deintercalation and addition of the compound of chemical formula 5. A therapeutic agent for inflammatory disease caused by SPC receptor activation contains the 2,4-double substitution-5-aminocarbonyl-1,3-thiazole derivative of chemical formula 1 or pharmaceutically acceptable salt as an active ingredient.