The present inventors have found that 2-D electrophoresis and used by asthma patients and healthy normal human bronchoalveolar lavage fluid (Bronchoalveolar lavage fluid, BALF) protein profile comparison was, asthma patients BALF in increased expression of the protein spots of the vitamin D binding protein ( DBP) was selected. In a mouse model validate the expression of increased sensitization to ovalbumin, and also a result of the treatment of the model mice sensitized with ovalbumin antibody anti -DBP, that reactive airway hypersensitivity, the number of inflammatory cells and cytokine production is significantly reduced was found out again verified the correlation between asthma and the DBP, it was confirmed that by attacking the rats directly into the DBP appear typical pathological symptoms of allergic asthma. The invention reveals a correlation of the DBP protein to hyeonryanggwa asthma, discloses a therapeutic agent of asthma using a diagnostic marker, DBP antibody or antisense for asthma using the same. ; 2-D electrophoresis, asthma, bronchial lavage fluid (BALF), vitamin D binding protein (DBP)
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