Two photon probe for real time monitoring of intracellular free zinc ions, method for preparing the same and method for real time monitoring of intracellular free zinc ions

摘要

For real-time monitoring of intracellular free zinc ions two-photon probes, a method of manufacturing the same, and there is provided a real-time monitoring method of the cytosolic free zinc ions using the same. ; Two-photon probes for real-time monitoring of intracellular free zinc ions present invention has a structure according to the formula 1, ; (One) ; Wherein, R is H or OCH _3. Two-photon probes in accordance with the present invention enables a very effective and long time monitoring of freedom with respect to the Zn ²⁺ in the cytoplasm which is located more deeply from a high selectivity has, with respect to the surface of Zn ^2+.