PRODUCING METHOD OF A CILASTATIN INTERMEDIATE CAPABLE OF PRODUCING A PRODUCT WITH HIGH YIELD AND HIGH PURITY BY EFFECTIVELY REMOVING IMPURITIES

摘要

PURPOSE: A producing method of a cilastatin intermediate is provided to obtain (Z)-7-hollow-2-((s)-2,2`-dimethylcyclopropane carboxamido)-2-heptenoic acid and its salt with high purity.;CONSTITUTION: A producing method of a cilastatin intermediate comprises the following steps: obtaining an (E,Z)-7-hollow-2-((s)-2,2`-dimethylcyclopropane carboxamido)-2-heptenoic acid alkali salt solution using a hydrolyzation after adding an alkali solution; extracting a first organic solvent layer from the reactant after adding a first organic solvent and acid to perform a layer separation; obtaining a mixed crystal of the (E,Z)-7-hollow-2-((s)-2,2`-dimethylcyclopropane carboxamido)-2-heptenoic acid alkali sa and obtaining (Z)-7-hollow-2-((s)-2,2`-dimethylcyclopropane carboxamido)-2-heptenoic acid amine salt.;COPYRIGHT KIPO 2010