APPLICATION OF DPP-IV INHIBITOR TO REDUCE GLYCEMIA ACTIONS

摘要

1. The use of a DPP-IV inhibitor or its salt in combination with at least one antidiabetic compound for the manufacture of a medicament for the reduction of hypoglycemia or severe hypoglycemia. ! 2. The use according to claim 1, where at least one antidiabetic compound is insulin. ! 3. The use of a DPP-IV inhibitor or its salt for the manufacture of a medicament for the reduction of hypoglycemia or severe hypoglycemia in patients after treatment with at least one antidiabetic compound. ! 4. The use according to claim 3, where at least one antidiabetic compound is insulin. ! 5. The course of diabetes treatment, according to which! i) a patient is selected who has been treated with at least one antidiabetic compound and who has episodes of hypoglycemia, preferably severe episodes of hypoglycemia,! ii) a DPP-4 inhibitor or a salt thereof is administered daily to said patient in combination with at least one antidiabetic compound according to (i), and optionally! iii) the daily dose of at least one antidiabetic compound according to (i) is gradually reduced to achieve the desired glucose level. ! 6. The treatment course according to claim 5, where the DPP-4 inhibitor or its salt is administered in combination with a reduced dose of at least one antidiabetic compound. ! 7. The course of treatment according to claim 5, where! i) a patient is selected who has been treated with insulin and who has episodes of hypoglycemia, preferably severe episodes of hypoglycemia,! ii) from 25 to 150 are administered daily to said patient